A Viable Alternative to Propecia in Treating Hair Loss?Folexen S-equol , produced by Australian manufacturer Eclipse Nutraceuticals is considered an "all natural" hair loss treatment that boasts an impressive 87% success rate for preventing and reversing the effects of male pattern baldness with virtually no side effects. Folexen S-equol has also been a hot topic of discussion on our popular hair loss forum. But, does this self-described "nutraceutical" live up to its hair growth hype? Is Folexen a viable alternative to Propecia for treating the effects of male pattern baldness?
According to the FAQ on Folexen's website, the active ingredient S-equol is "a metabolite of a natural isoflavone called daidzein, which occurs in soybeans and some other food products".
Isoflavones are an organic compound produced almost exclusively by various bean types. In populations that consume large quantities of soy protein, studies have shown a lower incidence of breast cancer and other common cancers because of its role in influencing sex hormone metabolism and biological activity.
As a metabolite, S-equol is the product that remains after the isoflavone is broken down or "metabolized" by the body.
In addition to its active ingredient, Folexen contains the following GRAS (generally recognized as safe) inactive ingredients: starch, maltodextrin, allantoin, propionic acid. It may also contain hypromellose (vegetarian capsule).
But is there any evidence that S-equol works to treat hair loss?
In the body, testosterone is converted to the hormone dihydrotestosterone (DHT) via the enzyme 5-alpha-reductase (5AR). It's widely known that androgenic alopecia (genetic hair loss) results when genetically vulnerable hair follicles are exposed to DHT which then binds to the receptor sites of these follicles causing them to weaken and shrink over time. This shrinking process is known as miniaturization.
The recognized leader in the battle against the balding effects of DHT is the clinically proven and FDA approved drug Propecia (finasteride). Propecia works by inhibiting the conversion of testosterone to DHT, potentially slowing or even reversing the effects of androgenic alopecia. However, approximately 2% of males who take Propecia experience debilitating sexual side effects.
Unlike finasteride, Folexen's rumored ability to suppress hair loss and potentially regrow hair is based on the theory that S-equol can bind strongly to free DHT molecules, prohibiting them from binding to the hair follicles' receptor sites. Because Folexen does not suppress the conversion of testosterone to DHT, there is no resulting increase of testosterone in the body and therefore, no sexual side effects. But are there any clinical studies supporting that S-equol can truly prevent DHT from binding to hair follicle receptor sites and prevent hair loss?
Folexen's website references four articles in peer reviewed journals. Two of these studies center on S-equol's effect on prostate health while the other two don't appear to reference S-equol at all.
At this time, there appears to be no scientific data presented supporting Folexen's efficacy as a hair loss treatment.
The company claims that the product is virtually side effect free: specifically noting that it does not cause gynecomastia (enlarged breasts), erectile dysfunction or any of the other side effects that are experienced with some other treatments.
Some users however, did report mild diarrhea that dissipated within one week of commencing treatment.
The recommended dosage of Folexen is 4 capsules per day (two every 12 hours), totaling 10mg of the active ingredient. Eclipse claims that the product has been tested safe at much higher concentrations (up to hundreds of milligrams) and there is some speculation based on available data that it may, in fact, require a dose as high as 100mg to match the Propecia's hair growth results.
Folexen is only available by mail order from Australia. A bottle of 100 2.5mg capsules (25 day supply) costs approximately $40 USD + shipping but there is a discount for purchases exceeding 4 bottles and again for 9+ bottles. However, it's easy to see that even in bulk this treatment is several times more expensive than purchasing generic 5mg finasteride and quartering the tablet, as many finasteride users do.
As a natural product and not a drug, there are no shipping restrictions. Estimated delivery time is two weeks.
Time will tell if Folexen S-equol proves to be an effective weapon in the fight against androgenic alopecia or simply another product in a long line of expensive disappointments.
In women with PCOS(polycystic ovarian syndrome), high levels of androgens (male hormones) in the body may cause hair loss. DHT (dihydrotestosterone), more abundant in men, is created from a combination of testosterone and5-alpha-reductase enzymes. DHT can bind to hair follicle sites, accelerate the natural hair growth cycle, and cause hair to go into resting (catagen) sooner causing thinning hair with each cycle.
Women with PCOS are more susceptible to androgenic alopecia, more commonly referred to as male pattern baldness or genetic female hair loss. Androgenic alopecia is also the number one cause of hair loss and thinning hair in the world.Women with androgenic alopecia typically lose hair in a pattern similar to the ludwig scale,and less commonly the norwood scale.
If you suspect you have PCOS, you should consult with a physician and get tested for it. Only a physician can diagnose you and recommend a proper treatment.
Revivogen hair loss treatment is a "3 in 1" all inclusive product that comes with scalp therapy, one eyedropper, one shampoo and one conditioner.
This topical scalp therapy treatment, equally effective for both men and women, claims to be very successful at inhibiting the 5-alpha reductase enzyme, which converts testosterone into DHT (dihydrotestosterone). The makers of Revivogen claim that it is even more effective than Propecia in reducing DHT in the scalp without the unwanted side effects. It's also potentially the most potent topical antiandrogen on the market. Antiandrogen hair loss treatments like Revivogen inhibit the production of the male hormone DHT. The makers of Revivogen claim that it is even more effective than Propecia in reducing DHT in the scalp without the unwanted side effects. This product however, has not been approved for hair loss by the FDA.
Revivogen all natural medicated shampoo is one of the few shampoos that includes ingredients scientifically supported to help inhibit the production of DHT and its binding to hair follicles. A 12oz bottle should last just under 2 months.
Revivogen shampoo has ingredients that complement the Scalp Therapy solution, increases scalp circulation, opens pores, and produces a cooling and refreshing menthol feeling on the scalp.
Revivogen Thickening Conditioner revives limp and thinning hair in men and women by moisturizing and strengthening the hair shaft. Natural proteins add natural volume, shine and create the appearance of thicker and fuller hair. For best use, we recommend using this conditioner with Revivogen Shampoo. Or, get the discounted Revivogen Shampoo and Conditioner combination instead to save money.
We strongly recommend using Nizoral shampoo every 2 or 3 days in conjunction with these treatments. Its active ingredient ketoconazolehas proven to be a moderate DHT inhibitor and has growth properties approximately as effective as Rogaine 2%.
Revivogen contains scientifically backed ingredients including Azelaic Acid, Vitamin B6, Zinc, Saw Palmetto, GLA and ALA which are fatty acids proven to inhibit the production of DHT. Reducing the amount of DHT in the body and scalp reduces the risk of vulnerable hair follicles dying and falling out.
For proper treatment, Revivogen should be applied at least once a day to the scalp's affected areas as well as the surrounding areas. Once you've used the medication, you should not wash your hair for at least three hours. This allows the active ingredients to be absorbed into your scalp The effects of Revivogen may take some time to work. Most users claim to experience their desired results after about 6 months of use.
Revivogen contains no reported side effects.
Men and women sometimes suffer from hair loss for different reasons. Thus, diagnosing its cause is necessary to facilitate and promote proper treatment. Revivogen is not clinically proven or approved by the FDA.
Revivogen and other antiandrogens (such as Propecia, Crinagen, Nizoral, Revita, etc.) may provide marginal benefit to men and women trying to maintain existing hair due to androgenic alopecia. Propecia by far is the most effective and only proven antiandrogen. For the best chance at regrowing hair non-surgically, adding a hair growth stimulant such as Rogaineor Tricomin is crucial.
Don't expect immediate results. It's recommended to use Revivogen for at least 6 to 12 months before determining its effectiveness. Documenting your progress with bi-monthly photos can help you determine whether or not Revivogen has been successful in helping you maintain existing hair.
To date, only surgical hair restoration is proven to grow hair in completely bald areas. You are invited to have a free virtual consultation with one of our prescreened hair restoration physicians.
Rogaine for women is the most recommended treatment for hair loss on the market for women today, and the only FDA approved and clinically proven treatment available for female hair loss sufferers.
Note: Despite what the insert says, Rogaine works just as well for frontal hair loss, recession, and thinning hair.
This product includes the original 2% minoxidil solution manufactured over 15 years ago. While it only reports a 46% success rate as opposed to the 5% liquid solution's 64% and the foam's impressive 85%, Rogaine for women reduces the possibility of unwanted side effects, including the unpopular unwanted facial and body hair growth.
Rogaine works by stimulating the hair follicles and revitalizing them. This sometimes stimulates the regrowth of miniaturizing hairs, promoting a thicker and fuller appearance of hair.
Rogaine for women is a good starting point for women with thinning hair. While it's not as effective as the 5% liquid solution or Rogaine foam, the possibility of side effects are reduced. Thus, women may want to start small and work their way up to the more advanced Rogaine solutions.
Don't expect immediate results. Just as hair loss is a slow process, regrowing it is too. Thus, it's recommended to use Rogaine for approximately 6 to 12 months before determining its effectiveness. Documenting your progress with bi-monthly photos can help you better evaluate the results.
Hair shedding is a common symptom the first few months and a sign that the medication may be working for you. It's crucial to push past this stage with continued use for the recommended period of time.
To date, only surgical hair restoration is proven to grow hair in completely bald areas. You are invited to have a free virtual consultationwith one of our prescreened hair restoration physicians.
Over the past several years surgeons have used various techniques to perform follicular unit hair transplantation. One such technique is the Lateral Slit Technique, also known as Coronal or Perpendicular Grafting. This technique’s name is derived from the angle and direction in which the graft incisions are made.
While there are other techniques for performing densely packed and highly refined follicular unit transplantation, the lateral slit technique offers a high degree of control over the angle and direction in which the transplanted hairs will ultimately grow.
The lateral slit technique has been used both intuitively and systematically for years by hair restoration physicians. However, it has recently gained popularity as a systematic and precise way of performing follicular unit hair transplantation.
Many of our physician members use the Lateral Slit Technique exclusively or in combination with other techniques for creating graft incisions. The lateral slit technique enables a surgeon to create graft incisions at varying angles (ranging from 10 to 90 degrees to the scalp), including very acute angles that will make the transplanted hair grow out lying flatter to the scalp. The ability to create incisions at very acute angles is particularly useful in areas such as the front temples and sides where the hair normally grows out lying flat on the scalp.
The lateral slit technique also helps enable a surgeon to determine the direction of the graft incisions. This then determines the ultimate direction of the transplanted hairs growth. Thus a surgeon can use this technique to control and vary both the direction and angle at which the transplanted hair will grow in order to mimic the subtle changes in hair direction that occur naturally.
Each graft incision is created by analyzing the neighboring hair so the surgeon can reproduce the correct hair pattern. As a result, as each transplanted hair emerges from the scalp it will grow and lay in a similar direction as its neighboring non-transplanted hairs.
Lateral slit incisions also tend to be more parallel to the scalp and thus more superficial and less invasive to the scalp’s underlying vascular structure. This parallel alignment also enables a physician to place more grafts per square centimeter with out the grafts compressing or popping up since the pressure exerted on the grafts does not push them upward from the scalp.
Some of our members use custom blade cutters to create tiny blades to make incisions that match the size and depth of each follicular unit graft being transplanted. This enables a surgeon to safely dense pack more grafts into a given area during a surgical session. Healing time is also more rapid, with minimal scarring.
Typically most clinic’s blades range from 1.5mm to 2mm in size. However, by using the custom blade cutter our physicians can create blades as small as .7mm for a single hair graft and .9mm for a multi hair graft.
In addition, the blades created by the custom cutter are squared off to match the shape of the bulb end of a hair follicle. Non custom cut blades are typically spear pointed which requires them to be inserted deeper thus causing more trauma to the scalps vascular structure.
The ability to control the depth of the incision each blade makes is also critical. Each blade is placed in a blade holder that is set to not allow the blade to go any deeper than required for the graft to being placed in the incision. This minimizes unnecessary trauma to the deep vasculature of the scalp, thus enabling close tight incisions, minimal tissue swelling, and quick healing that leaves no visible scaring, pitting, or cobble stoning of the scalp.
The plane and direction in which each follicular unit graft is placed on the scalp can also impact the ultimate appearance of density that can be produced with a given number of grafts. This is because hairs within a follicular unit are typically next to each other inline.
Therefore by arranging each multiple hair graft on the scalp in a linear fashion to the line of sight, each follicular unit will provide the maximum appearance of fullness and scalp coverage. This also mimics how hair is normally aligned on the scalp.
Special thanks to Dr. DeYarman, Dr. Sharon Keene, Dr. Jerry Cooley, Dr. Alexander, and Dr. Glenn Charles for contributing their expertise and photos for this section.
Currently the only solution for regrowing hair, particularly in the hairline area, is hair transplant surgery, an advanced surgical hair restoration technique.
Done right, a hair transplant is so natural that even a hair stylist cannot detect that a person has had hair transplants.
The days of the "corn row" or "Barbie Doll" hair transplants are long gone.
To achieve such truly natural results requires a dedicated and highly skilled staff doing a state of the art hair transplant procedure. The state of the art micro hair transplant procedure that our member physicians perform is called "Ultra Refined Follicular Unit Hair Transplantation".
Hair transplant surgery involves relocating (transplanting) the bald resistant hair follicles from the back of the head to the balding areas on the top and front of the head.
This process is effective and will last a lifetime because the hair follicles taken from the back of the head are genetically resistant to baldness, no matter where they are transplanted.
This procedure is regarded by most hair restoration physicians to be the "gold standard in hair transplants". Learn more about this hair transplant procedure.
Because this very refined procedure is difficult to perform at the highest quality level only a minority of all hair restoration surgeons perform it successfully. Our member physicians have extensive experience performing this advanced and very refined procedure with excellent proven results.
Today, hair transplant surgical hair restoration is an out-patient procedure requiring only local anesthesia. Most patients are surprised by how little discomfort they experience during and after their surgery. Many patients watch TV or sleep during their procedure.
Hair transplant surgery is the only certain way of restoring significant amounts of hair in balding areas. View hair transplant photos of actual hair loss patients.
Sharing information in the Hair Loss Learning Center forum with patients who have successfully restored their hair is a good way to begin the process of selecting a hair transplant surgeon with a proven record of restoring a natural hairline. Online consultation can put you directly in touch with one of the world's top hair restoration physicians in your area who can help you assess your options.