The "Active" Ingredient in Many Popular Hair Loss Treatment Products

Many popular hair loss treatment options today such as Provillus, Procerin, and Avacor contain the “active” ingredient saw palmetto. It can also be purchased as a standalone supplement in most nutritional stores. But the age old question of whether or not it can effectively treat baldness in men and women with alopecia is still heavily debated. By taking a look at the scientific evidence available we are able to draw some conclusions as to its potential benefit for those with thinning hair.

What is Saw Palmetto?

Saw Palmetto berries are a deep red fruit that grow wild on palm trees in warmer climates, typically found in the Southeastern United States. The liposerolic berry extract is typically used as an herbal supplement for the promotion of a healthy prostate.

Saw Palmetto Hair Loss Study:

Similarly to finasteride (the active ingredient in Propecia and Proscar), studies have shown that when taken orally, it may be an effective anti-androgen by lowering dihydrotestosterone (DHT) levels in the body by blocking 5 alpha-reductase enzymes. Additionally it is said to block receptor cites on cells which is required for cells to absorb DHT.

Tests have also been performed on its use in the treatment of benign prostatic disease, which similarly to androgenic alopecia, depends on the production of DHT.

It is also noteworthy to state that a small preliminary study in 2002 was performed as reported by The Journal of Alternative and Complementary Medicine(2002;8:143-52) that shows a select group of 19 men between the ages of 23 and 64 taking either (400mg of saw palmetto and 100mg of Beta-sitosterol) or a placebo orally. Those who took the herbal combination had 60% improved hair growth over those who took the placebo. There have been no studies to date indicating the efficacy of saw palmetto applied topically for male pattern baldness, female hair loss, or anything to date.

In our opinion, there are two potential difficulties with this study:

• Many scientists would argue that the control study group was too small to determine any real efficacy and improved hair growth could have happened by chance. A larger study therefore may be necessary to determine any level of real efficacy.
• “Improved hair growth” is not the same thing as newhair growth and hair regrowth, nor should it necessarily imply that it works to stop hair loss
• There are no regulations or suggested daily value as to how much saw palmetto would be required to successfully treat baldness. The appropriate dosage therefore is questionable.
• The above study was only performed on saw palmetto taken orally. Hair loss products that promote topical use for baldness are basing their belief in its efficacy on something other than published clinical evidence.

The Dosage:

But if there are no current standards on dosages of herbal medications in the United States, how do these popular hair loss treatments produce an appropriate dosage?

Clinical studies on Benign Prostrate Hyperplasia (BPH) have used a dosage of 320mg of the berry extract daily (either one 320mg pill or 2 X 160 mg pill). A daily dosage of 480 mg of saw palmetto berry extract was not found to be any more effective in a six-month study. If the entire berry was used, up to 1000mg or 2000mg would be required to reach the same goal.

The theory therefore is that if saw palmetto can successfully treat an enlarged prostate similarly to finasteride, it can effectively treat hair loss with a similar dosage Many popular “baldness cure” products contain approximately 1500mg of the berry which is equivalent to approximately 240-320mg of the berry extract.

Side Effects and Warnings:

One false assumption is that “all natural” treatments don’t have potential side effects. It is stated that use of saw palmetto has not proven to be safe for women with hair loss during pregnancy and lactation. Medical supervision is suggested for women of childbearing age. Similar warnings are listed about Propecia.

Conclusions:

Based on some anecdotal evidence, saw palmetto is said to treat baldness because of its tendency to act like finasteride by helping those suffering from BPH. However, authentic clinical studies have not been performed to date that support this claim. Dosage and how it should be used (orally or topically) therefore is based on conjecture rather that scientific evidence.

Crinagen is an all natural alcohol-free topical scalp spray clinically backed to reduce the amount of DHT (dehydrotestosterone) in the scalp. It contains no alcohol, and has displayed no side effects. Crinagen is also equally safe for men and women and is most effective in men and women with thinning hair. In addition to blocking scalp DHT, they both are reported nourish the scalp’s hair follicles. Crinagen usually displays its effects on average in five months.

How It Works:

The product's main ingredients are Saw Palmetto, Zinc, and Azelaic Acid. All 3 ingredients are reported to reduce the production of scalp DHT and nourish the scalp's hair follicles.

Developing Realistic Expectations:

Crinagen has not been clinically proven nor approved by the FDA. Thus, like Revivogen and Tricomin, Crinagen should be used only after seriously considering proven treatments like Propecia (finasteride) and Rogaine (minoxidil).

Don't expect immediate results. It's recommended to use Crinagen for at least 6 to 12 months before determining its effectiveness. Documenting your progress with bi-monthly photos can help you determine whether or not Crinagen is working for you.

Hair shedding is a common symptom the first few months and a sign that the medication may be working for you. It's crucial to push past this stage with continued use for the recommended period of time.

To date, only surgical hair restoration is proven to grow hair in completely bald areas. You are invited to have a free virtual consultation with one of our prescreened hair restoration physicians.

Revivogen hair loss treatment is a "3 in 1" all inclusive product that comes with scalp therapy, one eyedropper, one shampoo and one conditioner.

This topical scalp therapy treatment, equally effective for both men and women, claims to be very successful at inhibiting the 5-alpha reductase enzyme, which converts testosterone into DHT (dihydrotestosterone). The makers of Revivogen claim that it is even more effective than Propecia in reducing DHT in the scalp without the unwanted side effects. It's also potentially the most potent topical antiandrogen on the market. Antiandrogen hair loss treatments like Revivogen inhibit the production of the male hormone DHT. The makers of Revivogen claim that it is even more effective than Propecia in reducing DHT in the scalp without the unwanted side effects.  This product however, has not been approved for hair loss by the FDA.

Revivogen all natural medicated shampoo is one of the few shampoos that includes ingredients scientifically supported to help inhibit the production of DHT and its binding to hair follicles. A 12oz bottle should last just under 2 months.

Revivogen shampoo has ingredients that complement the Scalp Therapy solution, increases scalp circulation, opens pores, and produces a cooling and refreshing menthol feeling on the scalp.

Revivogen Thickening Conditioner revives limp and thinning hair in men and women by moisturizing and strengthening the hair shaft. Natural proteins add natural volume, shine and create the appearance of thicker and fuller hair. For best use, we recommend using this conditioner with Revivogen Shampoo. Or, get the discounted Revivogen Shampoo and Conditioner combination instead to save money.

We strongly recommend using Nizoral shampoo every 2 or 3 days in conjunction with these treatments. Its active ingredient ketoconazolehas proven to be a moderate DHT inhibitor and has growth properties approximately as effective as Rogaine 2%.

How It Works:

Revivogen contains scientifically backed ingredients including Azelaic Acid, Vitamin B6, Zinc, Saw Palmetto, GLA and ALA which are fatty acids proven to inhibit the production of DHT. Reducing the amount of DHT in the body and scalp reduces the risk of vulnerable hair follicles dying and falling out.

For proper treatment, Revivogen should be applied at least once a day to the scalp's affected areas as well as the surrounding areas.  Once you've used the medication, you should not wash your hair for at least three hours.  This allows the active ingredients to be absorbed into your scalp  The effects of Revivogen may take some time to work.  Most users claim to experience their desired results after about 6 months of use.

Revivogen contains no reported side effects.

Developing Realistic Expectations:

Men and women sometimes suffer from hair loss for different reasons. Thus, diagnosing its cause is necessary to facilitate and promote proper treatment. Revivogen is not clinically proven or approved by the FDA.

Revivogen and other antiandrogens (such as Propecia, Crinagen, Nizoral, Revita, etc.) may provide marginal benefit to men and women trying to maintain existing hair due to androgenic alopecia. Propecia by far is the most effective and only proven antiandrogen. For the best chance at regrowing hair non-surgically, adding a hair growth stimulant such as Rogaineor Tricomin is crucial.

Don't expect immediate results. It's recommended to use Revivogen for at least 6 to 12 months before determining its effectiveness. Documenting your progress with bi-monthly photos can help you determine whether or not Revivogen has been successful in helping you maintain existing hair.

To date, only surgical hair restoration is proven to grow hair in completely bald areas. You are invited to have a free virtual consultation with one of our prescreened hair restoration physicians.

Stemcelex is the newest product in a long line of hair restoration therapies claiming to “cure” hair loss via stem cell therapy. Given the recent onslaught of news regarding stem cell based hair loss treatments, injectable baldness cures, and research breakthroughs, it’s not surprising to see new therapies claiming to aggressively fight hair loss through these same mechanisms. However, is Stemcelex truly a stem cell based, regenerative hair loss cure, or is it another therapy simply riding the recent wave of interest in these types of non-invasive, revolutionary treatments?

At first glance, Stemcelex seems quite impressive. The product website is filled with scientific explanations, graphs, charts, and diagrams explaining the science behind stem cell based hair restoration. Stemcelex even states its affiliation with Dr. George Cotsarelis, a researcher at the University of Pennsylvania Medical Center who, along with a talented research team, recently discovered that the bald scalp does not suffer from a lack of stem cells, but rather a dysfunction in the pathway to properly activating stem cells to produce hair. The finding was significant and Dr. Cotsarelis’ involvement and the seemingly detailed science look promising, but what about Stemcelex itself? Does it utilize these scientific breakthroughs and offer an effective treatment for hair loss?

Unfortunately, despite the impressive name recognition and detailed explanations, Stemcelex doesn’t appear to live up to its lofty hair restoration claims. Despite claiming to “activate” the dormant stem cells described by Dr. Cotsarelis, Stemcelex does not offer any sort of feasible molecular/stem cell based therapy. The website cleverly explains the science behind stem cell inactivation and the promise of reversing the dysfunctional pathway, but instead of reinforcing Dr. Cotsarelis’ view that cures for reversing the inactivation pathway are not yet understood, Stemcelex claims to actually fix the stem cell inactivation through a series of unproven homeopathic and herbal treatments for hair loss.

So, what is actually inStemcelex? The treatment involves a three day cycle of different lotions and topical treatments for baldness applied twice a day.

Day1: On the first day of the hair restoration cycle, a topical lotion made from Jaborandi Pilocarpus is applied twice after washing and thoroughly drying one’s hair. According to Stemcelex, Jaborandi Pilocarpus is a parasympathetic activator (it excites the nerves that cause the body to “rest and digest” during periods of relaxation) that rids the scalp of excess oils and dandruff that impede healthy follicular hair growth. Furthermore, Stemcelex claims that Pilocarpus naturally darkens and thickens existing, native hairs. According to the experts, Pilocarpus has no reproducible pharmacological applications and any evidence that it actually thickens and darkens hair is anecdotal.

Day 2: The second day of the cycle involves Veratrum Lobelianum, a family of herbs commonly used in Chinese medicine.  Stemcelex claims these herbs can penetrate the scalp and activate the necessary molecular signaling to “regenerate” the hair follicle stem cells. Furthermore, Veratrum allegedly down-regulates or prevents the production of Dihydrotestosterone (DHT), the hormone directly responsible for male pattern baldness. According to the research, members of the Veratrum family have been used in everything from a Native American poison to a drug researched in human blood pressure.  Currently, they are used in cancer treatments. Although the science behind cancer therapies indicates that the drug could have some molecular benefit in signaling cell activation and inactivation, there has been no research or evidence suggesting that Veratrum is useful in fighting, reversing, or preventing the effects of male or female hair loss.

Day 3: During the third day of the Stemcelex cycle, a kelp based topical extract is applied twice daily to provide nutrients to the “new hair growth” and also ensure that the scalp remains clean and healthy. This step of the treatment doesn’t claim to be more than a simple dose of nutrients useful in good scalp hygiene.

After reviewing the active ingredients behind Stemcelex, there is no evidence to suggest that Stemcelex is an effective hair loss treatment at this point in time. The idea of activating the dormant stem cells is important to finding a molecular cure to hair loss, but despite understanding this importance, Stemcelex doesn’t offer any concrete stem cell reactivation agents. It’s possible that Veratrum may prove useful in cell signaling and reactivating dormant cells, but the current research and evidence simply don’t support its use at this time.  Furthermore, Stemcelex charges a hefty $99.85 for a month supply of the treatment which may keep even the most curious and enthusiastic hair loss suffering men and women away.

Altogether, the idea of reversing dormant hair follicle stem cells is important, but therapies for effectively stopping and rewiring this pathway do not seem to exist at this point in time. Unfortunately, this seems to nullify the claims made by Stemcelex and prevent it from becoming a stem cell hair loss cure.

Truly "Personal Care Luxury?"

Of all the types of concealers available today, one of the longest lasting may be the "spray on," color-matching aerosol topical. Although many brands and differing types of spray on concealers currently exist, ProTHIK is considered by many to be one of the most trusted. What makes this product so popular in the hair loss community? How does ProTHIK work to conceal hair loss? Is ProTHIK truly a "personal care luxury for men" like their website indicates?

ProTHIK: What is it, and how does it Work?

ProTHIK belongs to the popular "aerosol" variety of spray applications. It is applied properly by spraying an appropriate amount of the aerosolized solution onto balding areas of the scalp. Due to its resin technology and variety of natural color choices, spraying ProTHIK onto areas of the balding scalp or thinning hair eliminates unsightly "bald spots" and reportedly leaves the patient with a realistic looking and undetectable appearance. But what does ProTHIK offer that similar hair loss products do not?

The Benefits of ProTHIK

According to the manufacturers, ProTHIK is superior to similar products for a number of important reasons.

First, ProTHIK allegedly possesses superior rub-resistance, a single component formulation (meaning multiple applications during one sitting is not necessary), superior water resistance, and a greater overall durability.

Second, when applied to the scalp, ProTHIK supposedly creates a natural, undetectable appearance (to both visual and physical inspection) that is resistant to excessive amounts of sweat. What’s more, ProTHIK is proposed to last overnight or between showers, and washes off easily with basic shampoo.

Third, ProTHIK is designed to provide adequate coverage in a variety of hair loss scenarios. For example, ProTHIK is reportedly able to conceal scalp regions with only 10 to 15% remaining hair and "bald patches" as large as 3-4 centimeters in diameter.

ProTHIK Product Reviews

Like other aerosol products, ProTHIK is only recommended for areas of hair loss 1.5 - 1 inches posterior to the frontal hairline however, it's considered especially effective in the vertex (crown) region.  Despite the more specific application, ProTHIK remains popular with many consumers because of its overall effective nature, natural appearance, and lasting durability.  On the flip side, some ProTHIK users have expressed concerns about messy application and clogging.

Unlike similar products, ProTHIK reports that it requires fewer applications and its resin technology does not create a shiny, thickened, or "sticky" appearance when applied to areas of balding scalp.

Additionally, manufacturers of ProTHIK report that it remains effective in hair thinned up to 85 – 90% of its original density and bald patches as large as 3-4 centimetres in diameter. For these, and many other reasons, ProTHIK remains a popular, trusted choice for individuals seeking a quality aerosol concealer.

What Real Hair Loss Sufferers are Saying About ProTHIK

To learn what hair loss suffering men and women who've used ProTHIK are saying, visit our popular hair loss forum and social community.

Childbirth may result in hair loss. It's common for many women to notice hair loss about 3 months after they've had a baby. This too, is caused by hormones. But this is not something to worry about. You see, during pregnancy, hair that normally falls out is kept in by high levels of hormones. Once the hormones have returned to pre-pregnancy levels, this extra hair falls out. The normal cycle of hair growth and loss then begins again.